Pregnancy associated plasma protein A: an early predictor of fetal growth restriction

Background: The aim of our study was to determine the association low levels pregnancy associated plasma protein-A (PAPP-A) estimated at 11-13+6weeks gestation with fetal growth restriction (FGR).Methods: A prospective observational a total 203 pregnant women PAPP-A were followed up and outcome data collected childbirth.Results: incidence FGR 7.3%. significant found between MoM (≤0.49) (p=0.000) unadjusted odds ratio 11.6. At multiples median (MoM) ≤0.49, had (Q1, Q3) 0.46 (0.42, 1.54) versus 1.87 (0.59, 3.11) which statistically (p=0.05) moderate strength prediction [minus 0.58 (95% CI, minus 1.113, 0.055), p=0.03]. cut-off considered in i.e., ≤0.49 MoM, sensitivity, specificity, positive predictive value (PPV) negative (NPV) 73%, 81%, 23%, 97% respectively LR 3.82 0.32. Karl Pearson’s correlation showed (r=0.308, p<0.001) birthweight that for every unit increase increased by 0.082 times (approximately 90 gm). We also an pre-eclampsia, preterm delivery caesarean births.Conclusions: conclude are good reflectors placental function adverse outcomes. PAPP-A, part dual marker, may be extrapolated suspecting FGR. This could guide instituting appropriate feto-maternal surveillance.